MadSci Network: Biochemistry
Query:

Re: Does glycerophosphatide same as glycerophospholipids?

Date: Wed Aug 14 14:06:55 2013
Posted By: Steve Mack, Staff Scientist
Area of science: Biochemistry
ID: 1376320028.Bc
Message:

I do not understand whether glycerophosphatide and glycerophospholipids mean the same thing or not.
Are phosphatidylglycerols the same as glycerophosphatides and glycerophospholipids?

Glycerophosphatides (aka, glycerophospholipids or phosphoglycerides) are a specific subset of phospholipids with a glycerol backbone.

Here is the basic structure:
glycerophospholipid structure

In a glycerophosphatide, the hydroxyl group of glycerol carbon 3 is esterified to a phosphate group, while the carbon 1 and 2 hydroxyls are esterified to fatty acids. The phosphate can be further modified with other hydrophilic molecules, such as choline or ethanolamine (indicated as X in the figure above). The resulting molecules in these cases would be phosphatidylcholine (aka, lecithin) and phosphatidylethanolamine.

Here is the structure of phosphatidylcholine:
full lecithin structure

Phosphatidylglycerol is a particular type of glycerophosphatide in which the hydrophilic molecule modifying the phosphate (the X group) is a second glycerol.

Here is a good example of a phosphatidylglycerol:
phosphatidylglycerol: two glycerols, two fatty acids and a phosphate

The primary example of a phospholipid that is not a glycerophosphatitde is sphingomyelin, which has a sphingosine backbone instead of a glycerol backbone.

sphingomyelin

Reference:
Howard R. Petty. Molecular Biology of Membranes: Structure and Function. Chapter 2. Springer. 1993.


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