MadSci Network: Biochemistry |
I do not understand whether glycerophosphatide and glycerophospholipids mean the
same thing or not.
Are phosphatidylglycerols the same as glycerophosphatides and glycerophospholipids?
Glycerophosphatides (aka, glycerophospholipids or phosphoglycerides) are a specific subset of phospholipids with a glycerol backbone.
Here is the basic structure:
In a glycerophosphatide, the hydroxyl group of glycerol carbon 3 is esterified to a phosphate group, while the carbon 1 and 2 hydroxyls are esterified to fatty acids. The phosphate can be further modified with other hydrophilic molecules, such as choline or ethanolamine (indicated as X in the figure above). The resulting molecules in these cases would be phosphatidylcholine (aka, lecithin) and phosphatidylethanolamine.
Here is the structure of phosphatidylcholine:
Phosphatidylglycerol is a particular type of glycerophosphatide in which the hydrophilic molecule modifying the phosphate (the X group) is a second glycerol.
Here is a good example of a phosphatidylglycerol:
The primary example of a phospholipid that is not a glycerophosphatitde is sphingomyelin, which has a sphingosine backbone instead of a glycerol backbone.
Reference:
Howard R. Petty. Molecular Biology of
Membranes: Structure and Function.
Chapter 2. Springer. 1993.
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